The Lions (0-3) are off to their worst start since 2010, when they finished 6-10.
Matthew Stafford took a beating in the pocket for Detroit (0-2), which fell behind 14-0 early in the second quarter.
The Lions dominated the first half, but the San Diego Chargers rallied to stun Detroit.
Rookie running back Ameer Abdullah ran for 67 yards to help lift the Lions to a 23-3 preseason victory over the New York Jets on Thursday.
Ty Hallock, a former Lion, discusses what he expects to see from the team this year.
The Detroit Lions say Hall of Fame tight end Charlie Sanders has died at age 68.
The Detroit Lions selected Nebraska running back Ameer Abdullah in the second round of the NFL draft Friday night.
The Detroit Lions have drafted guard Laken Tomlinson of Duke in the first round Thursday night after trading down in a deal with Denver.
The Detroit Lions will feature in a Sunday Night and two Monday Night games this season.
The NFL is saying bye-bye to blackouts — at least for 2015.
The St. Louis Rams agreed to terms with defensive tackle Nick Fairley on a one-year free agent deal.
Five-time Pro Bowl defensive tackle Haloti Ngata of the Baltimore Ravens is headed to join the Detroit Lions.
The Miami Dolphins have pulled ahead in the Ndamukong Suh sweepstakes, and their lead may be insurmountable.
The Detroit Lions’ website is reporting that the team will not use the franchise tag on star defensive tackle Ndamukong Suh.
The Detroit Lions released running back Reggie Bush on Wednesday, halfway through the four-year deal he signed as a free agent.
Lions quarterback Matthew Stafford and wide receiver Golden Tate have been added to the Pro Bowl.